Original Research Articles and Reviews (2012-2023)
2023
Apoptotic exosome-like vesicles transfer specific and functional mRNAs to endothelial cells by phosphatidylserine-dependent macropinocytosis. Brodeur, A., Migneault, F., Lanoie, M., Beillevaire, D., Turgeon, J., Karakeussian-Rimbaud, A., Thibodeau, N., Boilard, E., Dieudé, M., Hébert, M. J. Cell Death & Disease, 14, 449 (2023).
Hypothermic Perfusion Modifies the Association Between Anti-LG3 Antibodies and Delayed Graft Function in Kidney Recipients. Mawad, H., Pinard, L., Medani, S., Chagnon, M., Boucquemont, J., Turgeon, J., Dieudé, M., Hamelin, K., Rimbaud, A. K., Belayachi, A., Yang, B., Collette, S., Sénécal, L., Foster, B. J., Hébert, M. J., & Cardinal, H. Transplant international : official journal of the European Society for Organ Transplantation, 36, 10749. (2023).
Double Pretransplant Positivity for Autoantibodies to LG3 and Angiotensin II Type 1 Receptor Is Associated With Alloimmune Vascular Injury in Kidney Transplant Recipients. Carroll, R., Turgeon, J., Deayton, S., Emery, T., Bilogrevic, F., Jahan, S., Rimbaud, A. K., Georges, B., Tavares-Brum, A., Hébert, M. J., & Cardinal, H. ransplantation direct, 9(2), e1437. (2023).
2022
Humoral immune responses against SARS-CoV-2 Spike variants after mRNA vaccination in solid organ transplant recipients. Tauzin, A., Beaudoin-Bussières, G., Gong, S. Y., Chatterjee, D., Gendron-Lepage, G., Bourassa, C., Goyette, G., Racine, N., Khrifi, Z., Turgeon, J., Tremblay, C., Martel-Laferrière, V., Kaufmann, D. E., Cardinal, H., Cloutier, M., Bazin, R., Duerr, R., Dieudé, M., Hébert, M. J., & Finzi, A. iScience, 25(9), 104990. (2022).
Extracellular vesicles beyond biomarkers: Effectors of antibody-mediated rejection. Dieudé, M. & Hébert, M.J. American journal of transplantation, 22(9):2131-2132. (2022).
Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes. Beillevaire, D., Migneault, F., Turgeon, J., Gingras, D., Rimbaud, A. K., Marcoux, G., Spino, C., Thibodeau, N., Bonneil, E., Thibault, P., Boilard, É., Dieudé, M., & Hébert, M. J. Cell Death & Disease, 13(2), 145. (2022).
2021
Caspase-3-dependent peritubular capillary dysfunction is pivotal for the transition from acute to chronic kidney disease after acute ischemia-reperfusion injury. Lan, S., Yang, B., Migneault, F., Turgeon, J., Bourgault, M., Dieudé, M., Cardinal, H., Hickey, M. J., Patey, N., & Hébert, M. J. American journal of physiology. Renal physiology, 321(3), F335–F351. (2021).
The Impact of Programmed Cell Death on the Formation of Tertiary Lymphoid Structures. Dieudé, M., Kaci, I., & Hébert, M. J. Frontiers in immunology, 12, 696311. (2021).
Acute Kidney Injury, Microvascular Rarefaction, and Estimated Glomerular Filtration Rate in Kidney Transplant Recipients. Doreille, A., Azzi, F., Larivière-Beaudoin, S., Karakeussian-Rimbaud, A., Trudel, D., Hébert, M. J., Dieudé, M., Patey, N., & Cardinal, H. Clinical journal of the American Society of Nephrology : CJASN, 16(3), 415–426. (2021).
Autophagy, tissue repair, and fibrosis: a delicate balance. Migneault, F., & Hébert, M. J. Matrix Biology, 100-101, 182–196. (2021).
2020
Apoptotic exosome-like vesicles regulate endothelial gene expression, inflammatory signaling, and function through the NF-κB signaling pathway. Migneault, F., Dieudé, M., Turgeon, J., Beillevaire, D., Hardy, M. P., Brodeur, A., Thibodeau, N., Perreault, C., & Hébert, M. J. Scientific reports, 10(1), 12562. (2020).
Autophagy drives fibroblast senescence through MTORC2 regulation. Bernard, M., Yang, B., Migneault, F., Turgeon, J., Dieudé, M., Olivier, M. A., Cardin, G. B., El-Diwany, M., Underwood, K., Rodier, F., & Hébert, M. J. Autophagy, 16(11), 2004–2016. (2020).
Extracellular vesicles derived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts. Dieudé, M., Turgeon, J., Karakeussian Rimbaud, A., Beillevaire, D., Qi, S., Patey, N., Gaboury, L. A., Boilard, É., & Hébert, M. J. American journal of transplantation, 20(3), 726–738. (2020).
2019
Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs. Hardy, M. P., Audemard, É., Migneault, F., Feghaly, A., Brochu, S., Gendron, P., Boilard, É., Major, F., Dieudé, M., Hébert, M. J., & Perreault, C. Scientific reports, 9(1), 7203. (2019).
Injury derived autoimmunity: Anti-perlecan/LG3 antibodies in transplantation. Dieudé, M., Cardinal, H., & Hébert, M. J. Human immunology, 80(8), 608–613. (2019).
New insights into immune mechanisms of antiperlecan/LG3 antibody production: Importance of T cells and innate B1 cells. Padet, L., Dieudé, M., Karakeussian-Rimbaud, A., Yang, B., Turgeon, J., Cailhier, J. F., Cardinal, H., & Hébert, M. J. American journal of transplantation, 19(3), 699–712. (2019).
2018
Caspase-3 Is a Pivotal Regulator of Microvascular Rarefaction and Renal Fibrosis after Ischemia-Reperfusion Injury. Yang, B., Lan, S., Dieudé, M., Sabo-Vatasescu, J. P., Karakeussian-Rimbaud, A., Turgeon, J., Qi, S., Gunaratnam, L., Patey, N., & Hébert, M. J. Journal of the American Society of Nephrology : JASN, 29(7), 1900–1916. (2018).
Endothelial Dysfunction in Kidney Transplantation. Cardinal, H., Dieudé, M., & Hébert, M. J. Frontiers in immunology, 9, 1130. (2018).
2017
The Emerging Importance of Non-HLA Autoantibodies in Kidney Transplant Complications. Cardinal, H., Dieudé, M., & Hébert, M. J. Journal of the American Society of Nephrology : JASN, 28(2), 400–406. (2017).
2016
Anti-LG3 Antibodies Aggravate Renal Ischemia-Reperfusion Injury and Long-Term Renal Allograft Dysfunction. Yang, B., Dieudé, M., Hamelin, K., Hénault-Rondeau, M., Patey, N., Turgeon, J., Lan, S., Pomerleau, L., Quesnel, M., Peng, J., Tremblay, J., Shi, Y., Chan, J. S., Hébert, M. J., & Cardinal, H. American journal of transplantation, 16(12), 3416–3429. (2016).
2015
The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection. Dieudé, M., Bell, C., Turgeon, J., Beillevaire, D., Pomerleau, L., Yang, B., Hamelin, K., Qi, S., Pallet, N., Béland, C., Dhahri, W., Cailhier, J. F., Rousseau, M., Duchez, A. C., Lévesque, T., Lau, A., Rondeau, C., Gingras, D., Muruve, D., Rivard, A., … Hébert, M. J. Science translational medicine, 7(318), 318ra200. (2015).
The perlecan fragment LG3 regulates homing of mesenchymal stem cells and neointima formation during vascular rejection. Pilon, E. A., Dieudé, M., Qi, S., Hamelin, K., Pomerleau, L., Beillevaire, D., Durocher, Y., Zutter, M., Coutu, D., Perreault, C., & Hébert, M. J. American journal of transplantation, 15(5), 1205–1218. (2015).
2014
Autophagy fosters myofibroblast differentiation through MTORC2 activation and downstream upregulation of CTGF. Bernard, M., Dieudé, M., Yang, B., Hamelin, K., Underwood, K., & Hébert, M. J. Autophagy, 10(12), 2193–2207. (2014).
2013
A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells. Pallet, N., Sirois, I., Bell, C., Hanafi, L. A., Hamelin, K., Dieudé, M., Rondeau, C., Thibault, P., Desjardins, M., & Hebert, M. J. Proteomics, 13(7), 1108–1120. (2013).
Antiperlecan antibodies are novel accelerators of immune-mediated vascular injury. Cardinal, H., Dieudé, M., Brassard, N., Qi, S., Patey, N., Soulez, M., Beillevaire, D., Echeverry, F., Daniel, C., Durocher, Y., Madore, F., & Hébert, M. J. American journal of transplantation, 13(4), 861–874. (2013).
2012
Caspase activation regulates the extracellular export of autophagic vacuoles. Sirois, I., Groleau, J., Pallet, N., Brassard, N., Hamelin, K., Londono, I., Pshezhetsky, A. V., Bendayan, M., & Hébert, M. J. Autophagy, 8(6), 927–937. (2012).
The perlecan fragment LG3 is a novel regulator of obliterative remodeling associated with allograft vascular rejection. Soulez, M., Pilon, E. A., Dieudé, M., Cardinal, H., Brassard, N., Qi, S., Wu, S. J., Durocher, Y., Madore, F., Perreault, C., & Hébert, M. J. Circulation research, 110(1), 94–104. (2012).
